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This has been around for a while, but news to me. In my never ending quest to produce the most healthy pups I will be trying this with my next litter. It being a Frenchie litter it should be easier to tell if there is a difference since they always deliver by C-section. I will post an update if there is a substantial difference in the health of the pups.

Frozen plasma to be the only natural immune booster for newborn pups. Breeders have reported that pups fed plasma in the first 48 hours show consistent weight gain and are more vigorous than previous litters.

“Fading pups” are never a concern with pups boosted with plasma. Because the newborn’s digestive system is not completely operational for the first hours after birth, the molecular immune boosting components of the frozen plasma pass unobstructed into the pup’s circulation.
If the bitch has a caesarian section, providing frozen plasma for the pups becomes even more important as the quality of the bitch’s first colostrum may be compromised due to post-surgical antibiotic therapy.

W. Jean Dodds, DVM

One important use of blood plasma is to provide a source of globulins (plasma protein
antibodies) to protect weak, fading or orphan newborns against the common infectious agents
to which they are exposed. Plasma treatment [canine fresh-frozen plasma (FFP)] for orphaned
puppies or for those receiving only minimal colostrum after birth should be given in the first 24-
48 hrs of life. Treatment for healthy newborns may be repeated at 5 to 14 days of age and
then again at 3 to 4 weeks of age. For sick newborns, more frequent transfusions of FFP may
be necessary. These transfusions are usually given intraperitoneally (IP), but they can also be
given orally (by mouth) in the first 24 -36 hours of life [as FFP is salty, it should be followed
with a little drop of honey or syrup on the tongue]. When puppies are two days of age or older,
the route of administration must be IP (or IV or subcutaneously) and not oral, as the antibodies
in plasma will no longer be absorbed through the gastrointestinal tract.

The recommended dose is 3-5 mL per pound of body weight (0.25 x weight of puppy in
ounces = the amount of plasma given in mL or cc) and is given to each puppy orally, IP or
subcutaneously. Do not give more than 10 mL at one time.

Do not mix FFP with any solution, including formula, Lactated Ringers, water, etc. The
plasma by itself is very stable, but addition of any foreign solution may adversely affect
the chemical composition of the plasma.FFP can be refrozen after thawing without loss of viability.

After thawing, a tube can be re-frozen as
long as it has not been left out at room temperature for more than 1 hour. Similarly, if only part
of a tube is used or needed, the remainder of the tube can be placed in the refrigerator for 24
hours and then should be re-frozen. There will not be any loss of albumin and globulin
activities for up to 5 years, however, coagulation factors, which are typically used for bleeding
disorders not found in newborns, diminish after 1 year.


  • Dodds, WJ. 1993. Known medical indications for using fresh-frozen plasma. DVM

Newsmagazine 24(4): 42-43.

  • Poffenberger EM, Olson, PN, Chandler, ML, et al. 1991. Use of adult dog serum as a substitute

for colostrum in the neonatal dog. Am J Vet Res 52: 1221-1224.

  • Bouchard, G, Plata-Madrid, H, Youngquist, RS et al. 1992. Absorption of an alternate source of

immunoglobulin in pups. Am J Vet Res 53: 230-233.

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